C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2597097
Methods of treatment of various bone indications, such as osteoporosis, in a mammal are provided wherein an effective amount of an antagonist that .binds to a B-cell surface marker, such as a CD20 antibody, is administered, optionally also with another medicament such as an agent that treats such disorders in an effective amount. Articles of manufacture are also provided. Further, a method of inhibiting osteolysis in a mammal is provided comprising introducing into said mammal an isolated odontoprogenitor or osteoprogenitor cell comprising a nucleic acid encoding an antibody that binds to a B-cell surface marker.
L'invention concerne des méthodes permettant de traiter des indications osseuses variées, telles que l'ostéoporose, chez un mammifère, une quantité efficace d'antagoniste qui se lie à un marqueur de surface cellulaire de lymphocyte B, tel qu'un anticorps CD20, étant administrée, éventuellement avec un autre médicament, tel qu'un agent en quantité efficace pour traiter lesdits troubles. L'invention concerne également des articles de production. L'invention concerne en outre une méthode permettant d'inhiber une ostéolyse chez un mammifère par introduction dans ce mammifère d'un odontoprogéniteur isolé ou d'une cellule ostéoprogénitrice comprenant un acide nucléique codant pour un anticorps qui se lie à un marqueur de surface cellulaire de lymphocyte B.
Quan Joanne
Sewell K. Lea
Genentech Inc.
Smart & Biggar
LandOfFree
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