Treatment of bone disorders by modulation of fgfr3

Details Treatment of bone disorders by modulation of fgfr3 Treatment of bone disorders by modulation of fgfr3

A - Human Necessities

61

K

A61K 38/18 (2006.01) C12N 5/077 (2010.01) A61P 19/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2432257

The present invention relates to identifying genes that are differentially regulated or expressed in bone deposition disorders. Specifically, Fibroblast Growth Factor Receptor-3 (FGFR3) has been identified as being differentially regulated during the maturation of osteoblasts and whose expression can be correlated, for example, with bone deposition disorders such as osteoporosis (including correlation with degrees of severity of the disease).

La présente invention concerne l'identification de gènes régulés ou exprimés différemment dans des maladies de dépôt osseux. Plus spécifiquement, on a déterminé que le récepteur-3 du facteur de croissance fibroblastique (FGFR3) est régulé différemment lors de la maturation d'ostéoblastes, et que l'expression dudit récepteur peut être mise en relation avec, par exemple, des maladies de dépôt osseux telles que l'ostéoporose, l'expression dudit récepteur pouvant également être mise en relation avec les degrés de sévérité de la maladie.

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