A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/00 (2006.01) A61K 31/455 (2006.01) A61K 31/57 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61K 38/18 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2436847
This invention provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to at least 15 % of normal in cancer cells, a pyrimidine antagonist, and an anticancer agent to which the treated cancer is sensitive. This invention also provides a composition comprising a combination of ATP-depleting agents at concentrations which deplete the ATP level to at least 15 % of normal in cancer cells, a pyrimidine antagonist, and an anticancer agent to which the treated cancer is sensitive. Finally this invention provides a pharmaceutical composition comprising the above composition or a combination thereof and a pharmaceutically acceptable carrier.
La présente invention concerne une méthode permettant de traiter un sujet cancéreux, comprenant l'administration audit sujet d'une combinaison d'agents induisant la déplétion en ATP à des concentrations induisant la déplétion en ATP jusqu'au moins 15 % de la normale dans les cellules cancéreuses, d'un antagoniste de la pyrimidine et d'un agent anticancéreux auquel le cancer traité est sensible. Cette invention concerne également une composition comprenant une combinaison d'agents induisant la déplétion en ATP à des concentrations induisant la déplétion en ATP jusqu'au moins 15 % de la normale dans les cellules cancéreuses, un antagoniste de la pyrimidine, et un agent anticancéreux auquel le cancer traité est sensible. Enfin, ladite invention concerne une composition pharmaceutique comprenant la composition mentionnée ci-dessus ou une combinaison de cette dernière et d'un excipient pharmaceutiquement acceptable.
Bertino Joseph R.
Koutcher Jason
Martin Daniel S.
Gowling Lafleur Henderson Llp
Sloan-Kettering Institute For Cancer Research
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