Treatment of cancer patients exhibiting activation of the...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/496 (2006.01) A61K 31/138 (2006.01) A61K 31/4725 (2006.01) A61P 35/00 (2006.01) G01N 33/52 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2614392

The present invention relates to a method of determining P-glycoprotein expression and/or function for a patient with solid tumors, leukemias, and other malignancies. The invention also relates to using a P-glycoprotein expression and/or function diagnostic in conjunction with methods for treating solid tumors, leukemias, and other malignancies with a chemotherapeutic agent in combination with zosuquidar. The methods are particularly effective in treating acute myelogenous leukemia, metastatic breast cancer, and other cancers expressing P-glycoprotein, wherein the P-glycoprotein expression and/or function is used to select a treatment option for the patient.

L'invention concerne un procédé permettant de déterminer l'expression et/ou la fonction de la glycoprotéine P chez un patient présentant une tumeur solide, une leucémie ou d'autres tumeurs malignes. L'invention concerne aussi l'utilisation conjointe du diagnostic de l'expression et/ou de la fonction de la glycoprotéine P, et de méthodes de traitement de tumeurs solides, de leucémies et d'autres tumeurs malignes à l'aide d'un agent chimiothérapeutique combiné au zosuquidar. Ces méthodes sont particulièrement efficaces dans le traitement de la leucémie myélogène aiguë, le cancer du sein métastatique et d'autres cancers exprimant la glycoprotéine P, l'expression et/ou la fonction de la glycoprotéine P permettant de choisir une option de traitement pour le patient.

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