A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) A61P 35/00 (2006.01) C12N 15/20 (2006.01) C12N 15/21 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2309766
The present invention provides a pharmaceutical composition, comprising a non- infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon .omega. and one or more cationic compounds. The present invention also provides methods of treating cancer in a mammal, comprising administering into a tissue of the mammal a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding a cytokine. In addition, the present invention also relates to the methodology for selective transfection of malignant cells with polynucleotides expressing therapeutic or prophylactic molecules in intracavity tumor bearing mammals. More specifically, the present invention provides a methodology for the suppression of an intra-cavity dissemination of malignant cells, such as intraperitoneal dissemination.
L'invention concerne une composition pharmaceutique comprenant une construction polynucléotidique non infectieuse et non intégrante, comportant un polynucléotide codant un interféron omega , et un ou plusieurs composés cationiques. Elle porte aussi sur des méthodes de traitement du cancer chez un mammifère, qui consiste à administrer dans un tissu dudit mammifère, une construction polynucléotidique non infectieuse et non intégrante, comprenant un polynucléotide codant une cytokine. De plus, l'invention se rapporte à une méthodologie pour la transfection sélective de cellules malignes à l'aide de polynucléotides exprimant des molécules thérapeutiques ou prophylactiques, dans des mammifères porteurs de tumeurs intracavités. Plus spécifiquement, l'invention concerne une méthodologie pour la suppression d'une dissémination intracavité de cellules malignes, comme la dissémination intrapéritonéale.
Felgner Philip
Horton Holly
Manthorpe Marston
Parker Suezanne
Mbm Intellectual Property Law Llp
Vical Incorporated
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