A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2675979
The present invention provides compositions and uses thereof for treating cancer with DAST, 4 {4- [3- (4-chloro-3-trif luoromethyl phenyl) -ureido] -3 -fluorophenoxy} -pyridine-2-carboxylic acid methylamide of the formula I, including all polymorphs, hydrates, pharmaceutically acceptable salts, metabolites, prodrugs, solvates or combinations thereof. Any cancer can be treated, including cancers that have acquired resistance to another therapeutic agent, such as kinase inhibitors. DAST can also be used to treat cancers which have become refractory to other chemotherapeutic agents.
La présente invention concerne des compositions et procédés permettant de traiter le cancer avec DAST, c'est-à-dire le méthylamide de l'acide 4{4-[3-(4-chloro-3-trifluorométhyl phényl)-uréido]-3-fluorophénoxy}-pyridine-2-carboxylique représenté par la formule (I), y-compris tous leurs polymorphes, hydrates, sels pharmaceutiquement admis, métabolites, promédicaments, solvates ou combinaisons. Tout cancer peut être traité, y-compris les cancers qui ont acquis de la résistance à un autre agent thérapeutique tels que les inhibiteurs des kinases. DAST peut également s'utiliser pour traiter des cancers qui sont devenus réfractaires à d'autres agents chimiothérapeutiques.
Gedrich Richard W.
Wilhelm Scott
Bayer Healthcare Llc
Smart & Biggar
LandOfFree
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