Treatment of carcinomas using squalamine in combination with...

A - Human Necessities – 61 – K

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A61K 31/575 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2252584

A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds. As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, adriamycin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents. The cytotoxic chemical compound and the squalamine may be administered by any suitable route. The first treatment procedure may take place prior to the second treatment procedure, after the second treatment procedure, or the two treatment procedures may take place simultaneously. In one example, the first treatment procedure (e.g., a one time intravenous dosage of BCNU) is completed before the second treatment procedure with squalamine begins. As an alternative, the first treatment procedure may be a conventional radiation treatment regimen.

L'invention porte sur un procédé de traitement d'une tumeur comportant une première forme de traitement faisant appel à une technique classique de traitement du cancer et une deuxième forme de traitement consistant à administrer une dose efficace de squalamine. La première forme de traitement peut recourir à un ou plusieurs composés chimiques cytotoxiques usuels tels que le nitrosourée, (par exemple le BCNU), la cyclophosphamide, l'adriamycine, le 5-fluorouracil, le paclitaxel et ses dérivés, le cisplatine ou autres agents de traitement du cancer contenant du platine. Les composés chimiques cytotoxiques et la squalamine peuvent s'administrer par toute voie appropriée. La première forme de traitement peut avoir lieu avant la deuxième, ou les deux peuvent intervenir simultanément. Dans un exemple, la première forme de traitement (soit une dose intraveineuse de BCNU administrée en une fois) est achevée avant que la deuxième utilisant la squalamine ne commence. La première forme de traitement peut également consister en une radiothérapie de type usuel.

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