Treatment of celiac disease with interleukin-15 antagonists

Details Treatment of celiac disease with interleukin-15 antagonists Treatment of celiac disease with interleukin-15 antagonists

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 9/02 (2006.01) A61K 9/20 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2333923

The invention relates to the treatment of inflammatory bowel diseases, such as celiac disease with interleukin-15 (IL-15) antagonists. Preferably the antagonists are muteins of IL-15, antibodies against IL-15 or IL-15 molecules bound to chemical groups that interfere with the ability of IL-15 to effect a signal transduction through either the .beta. or .gamma.-subunit of the IL-15 receptor complex, but which do not interfere with IL-15 binding to IL- 15R.alpha..

La présente invention concerne le traitement de maladies inflammatoires de l'intestin, telle que la maladie coeliaque, à l'aide d'antagonistes de l'interleukine-15 (IL-15). De préférence, les antagonistes sont des mutéines de l'IL-15, des anticorps contre l'IL-15 ou des molécules d'IL-15 liées à des groupes chimiques qui interfèrent avec l'aptitude de l'IL-15 à effectuer une transduction de signal via les sous-unités .beta. ou .gamma. du complexe récepteur de l'IL-15, mais qui n'interfèrent pas avec la liaison de l'IL-15 avec l'IL-15R.alpha..

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