A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 38/47 (2006.01) A61K 38/51 (2006.01) A61P 25/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2478645
The invention provides a method of promoting neuronal plasticity in the CNS of a mammal, the method comprising administering to the CNS of the mammal an agent that reduces the inhibitory properties of chondroitin sulphate proteoglycans. Preferred agents are chondroitinases and sulfatases, e.g. chondroitinase ABC. Also provided are methods of identifying further agents.
La présente invention concerne une méthode permettant de favoriser la plasticité neuronale dans le système nerveux central d'un mammifère. Cette méthode consiste à administrer au système nerveux central du mammifère un agent qui réduit les propriétés inhibitrices des protéoglycanes de sulfate de chondroïtine. Les agents privilégiés dans cette invention sont les chondroïtinases et les sulfatases, par exemple, la chondroïtinase ABC. La présente invention concerne également des méthodes permettant d'identifier d'autres agents.
Bradbury Elizabeth Jane
Fawcett James
Mcmahon Stephen Brendan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cambridge Enterprise Limited
Cambridge University Technical Services Limited
King's College London
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