Treatment of central nervous system disorders by use of pdgf...

A - Human Necessities – 61 – K

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A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2461176

The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder. The reagent used is platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), a combination of both, a PDGF agonist or a VEGF agonist.

L'invention concerne généralement des méthodes propres à influencer des cellules du système nerveux central afin de produire une descendance utile dans le traitement de troubles du SNC. En particulier, l'invention concerne des méthodes d'exposition d'un patient atteint d'un tel trouble à un réactif modulant la prolifération, la migration, la différenciation et la survie des cellules du système nerveux central. Ces procédés sont utiles pour réduire au moins un symptôme du trouble.

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