C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2286455
The present invention provides a method of treating depression, mood swings, or Alzheimer's disease in a patient in need of such treatment by administering a selective estrogen receptor modulating compound of formula (a), in which R1 and R2 are independently hydroxy and alkoxy of one to four carbon atoms; and R3 and R4 are independently methyl or ethyl, or R3 and R4, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl- pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.
La présente invention concerne une méthode de traitement de la dépression, des sautes d'humeur ou de la maladie d'Alzheimer chez un patient nécessitant un tel traitement, consistant à administrer un composé sélectif modulant les récepteurs d'estrogènes, de la formule (a) dans laquelle R?1¿ et R?2¿ représentent indépendamment hydroxy et alcoxy contenant 1 à 4 atomes de carbone, et R?3¿ ainsi que R?4¿ représentent indépendamment méthyle ou éthyle, ou R?3¿ et R?4¿, pris ensemble avec l'atome d'azote auquel ils sont fixés, forment un cycle pyrrolidino, méthyl-pyrrolidino, diméthylpyrrolidino, pipéridino, morpholino, ou hexaméthylènimino.
Bales Kelly Renee
Bryant Henry Uhlman
Knadler Mary Patricia
Paul Steven Marc
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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