C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A21D 2/26 (2006.01) A21D 6/00 (2006.01) A23J 3/34 (2006.01) A23L 1/015 (2006.01) A23L 1/03 (2006.01) A23L 1/305 (2006.01) C12N 9/10 (2006.01)
Patent
CA 2667834
The present invention relates to the use of an enzymatic method for treating flour, semolina and protein extracts derived from cereals known to stimulate a pathological immune response in patients affected by Celiac Disease (CD). Said treatment drastically reduces or completely eliminates the toxicity of gluten or similar products derived from other cereals. The method uses the catalytic activity of microbial transglutaminase and, in particular, its ability to bind proteins in cereal flour or semolina to an alkylated (C1-C4) derivative of lysine. After the treatment said proteins extracted from flour show a substantially lowered immuno-stimulatory activity in celiac patients T lymphocytes.
La présente invention concerne l'utilisation d'un procédé enzymatique pour traiter la farine, la semoule et des extraits protéiques issus de céréales connues pour stimuler une réponse immunitaire pathologique chez des patients affectés par la maladie coeliaque (CD). Ledit traitement réduit de façon sensible ou élimine complètement la toxicité du gluten ou de produits analogues issus d'autres céréales. Le procédé utilise l'activité catalytique d'une transglutaminase microbienne et, en particulier, son aptitude à lier des protéines dans la farine ou semoule de céréale à un dérivé alkylé en C1-C4 de la lysine. Après le traitement, lesdites protéines extraites de la farine ont une activité immunostimulatrice sensiblement diminuée dans les lymphocytes T des patients coeliaques.
Gianfrani Carmela
Rossi Mauro
Siciliano Rosa Anna
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Consiglio Nazionale Delle Ricerche
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