Treatment of cervical cancer

Details Treatment of cervical cancer Treatment of cervical cancer

C - Chemistry, Metallurgy

12

N

C12N 15/37 (2006.01) A61K 48/00 (2006.01) C07K 14/025 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2342289

Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.

Ces vecteurs permettant une immunisation par ADN contre le cancer du col utérin renferment une molécule d'acide nucléique codant au moins un épitope non toxique de lymphocyte T de l'antigène E6 et/ou de l'antigène E7 d'une souche de papillomavirus humain (HPV) associé au cancer du col utérin, le HPV-16 notamment, et un agent promoteur couplé opérationnellement à la molécule d'acide nucléique aux fins de l'expression de la molécule d'acide nucléique chez le sujet à qui est administré le vecteur.

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