Treatment of chronic myelogenous leukemia, resistant or...

A - Human Necessities – 61 – K

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Details

A61K 31/55 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/7068 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2459822

The present invention concerns a method of treating chronic myelogenous leukemia, a related myeloproliferative disorder or a Ph-positive acute lymphocytic leukemia in a subject animal, comprising: (a) selecting or identifying an animal suffering from chronic myelogenous leukemia or a related myeloproliferative disorder and showing resistance or intolerance to treatment with STI571; and (b) administering to the animal homoharringtonine. In a preferred embodiment, the animal is a human being.

La présente invention concerne une méthode permettant le traitement de la leucémie myéloïde chronique, d'un syndrome myéloprolifératif associé ou d'une leucémie aiguë lymphoblastique à pH positif chez un animal. La méthode décrite dans cette invention consiste: (a) à sélectionner ou à identifier un animal atteint d'une leucémie myéloïde chronique ou d'un syndrome myéloprolifératif associé et présentant une résistance ou une intolérance au traitement au STI571; puis, (b) à administrer de l'homoharringtonine à cet animal. Dans un mode de réalisation préféré, l'animal est un être humain.

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