Treatment of chronic pain with zinc finger proteins

Details Treatment of chronic pain with zinc finger proteins Treatment of chronic pain with zinc finger proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2714378

A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating chronic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having chronic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing chronic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., Nay 1.8) can be repressed.

La présente invention concerne une variété de protéines en doigt de zinc (ZFP) et des méthodes dutilisation de telles protéines pour le traitement de la douleur chronique. Linvention concerne également des ZFP qui se lient à un site cible dans des gènes exprimés de manière aberrante chez des sujets souffrant dune douleur chronique. Linvention concerne de plus des ZFP qui se lient à un site cible dans des gènes exprimés à des niveaux normaux chez des sujets souffrant dune douleur chronique ainsi que la modulation des gènes dont lexpression conduit à une perception réduite de la douleur. Il est par exemple possible de réprimer des gènes surexprimés dans les ganglions de la racine dorsale (GRD) de patients souffrant dune douleur (notamment Nav1.8).

Affiliated with

Also associated with

Rating

Treatment of chronic pain with zinc finger proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of chronic pain with zinc finger proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of chronic pain with zinc finger proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1798833