Treatment of cns disorders with trans...

Details Treatment of cns disorders with trans... Treatment of cns disorders with trans...

C - Chemistry, Metallurgy

07

C

C07C 211/42 (2006.01) A61K 31/135 (2006.01) C07C 209/62 (2006.01)

Patent

CA 2498152

Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4- dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-~4-(3,4- dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl~formamide, which are also useful.

La présente invention concerne le traitement des troubles du système nerveux central avec de la (1<I>R,</I> 4<I>S</I>)-trans 4-(3,4-dichlorophényl)-1,2,3,4-tétrahydro-1-napthalénamine; et la (1<I>R</I>, 4<I>S</I>)-trans 4-(3,4-dichlorophényl)-1,2,3,4-tétrahydro-1-napthalénamine; ainsi qu'un procédé de préparation de 4-(3,4-dichlorophényl)-1,2,3,4-tétrahydro-1-napthalénamine. Le procédé comprend la préparation des quatre isomères de <I>N</I>-Ý4-(3,4-dichlorophényl)-1,2,3,4-tétrahydronaphthalen-1-yl¨formamide, qui sont également très utiles.

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