A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01)
Patent
CA 2615370
A method and formulation are provided for the treatment of medical conditions associated with the formation and/or deposition of macromolecular aggregates, particularly those associated with adverse ocular conditions. The formulation contains a non-cytotoxic chelating agent containing at least three negatively charged chelating atoms and a charge-masking agent containing at least one polar group and having a molecular weight of less than about 250, wherein the molar ratio of the charge-masking agent to the chelating agent is sufficient to ensure that substantially all negatively charged chelating atoms are associated with a polar group on the charge-masking agent.
L'invention concerne un procédé et une formulation pour le traitement d'affections médicales associées à la formation et/ou au dépôt d'agrégats macromoléculaires, notamment ceux associés aux affections oculaires critiques. Cette formulation contient un agent chélateur non cytotoxique contenant au moins trois atomes de chélation chargés négativement et un agent de masquage de charge contenant au moins un groupe polaire et possédant un poids moléculaire de moins d'environ 250, le rapport molaire entre l'agent de masquage de charge et l'agent chélateur étant suffisant pour assurer que sensiblement tous les atomes de chélation chargés négativement soient associés à un groupe polaire sur l'agent de masquage de charge.
Bhushan Rajiv
Gin Jerry B.
Chakshu Research Inc.
Fetherstonhaugh & Co.
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