Treatment of conditions caused by calcium abnormalities

Details Treatment of conditions caused by calcium abnormalities Treatment of conditions caused by calcium abnormalities

A - Human Necessities

61

K

A61K 31/58 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2587263

In certain aspects, the invention relates to use of PKD2 agonists, such as triptolide and triptolide derivatives, to regulate calcium release. In other aspects, the invention relates to use of PKD2 agonists to treat or aid in the treatment of any condition in which a calcium channel, such as the gene product of PKD 1 and/or PKD2, is mutated; calcium signaling is abnormal; or both, such as polycystic kidney disease.

L'invention concerne, dans certains aspects, l'utilisation d'agonistes de PKD2, par exemple le triptolide et les dérivés de triptolide, pour réguler la libération du calcium. Dans d'autres aspects, elle concerne l'utilisation d'agonistes de PKD2 pour traiter ou contribuer à traiter tout état dans lequel mute un canal calcique, par exemple le produit génique de PKD1 et/ou de PKD2, mute; la signalisation calcique est anormale; ou dans les deux cas.

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