Treatment of conditions involving amyloid plaques

Details Treatment of conditions involving amyloid plaques Treatment of conditions involving amyloid plaques

A - Human Necessities

61

K

A61K 38/02 (2006.01) A61K 38/16 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2522649

The invention provides methods for treating diseases involving aberrant amyloid-.beta. (A.beta.) peptide deposition, including Alzheimer~s Disease, by the administration of Nogo receptor antagonists. The invention also provides method for reducing levels of A.beta. peptide in a mammal by the administration of soluble Nogo receptor polypeptides

La présente invention concerne des procédés destinés au traitement d'affections impliquant un dépôt aberrant de peptides d'amyloïde B (AB), y compris la maladie d'Alzheimer, par administration d'antagonistes du récepteur Nogo. L'invention concerne également un procédé permettant de faire descendre les niveaux du peptide AB chez un mammifère par administration de polypeptides solubles du récepteur Nogo.

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