Treatment of congestive heart failure

A - Human Necessities – 61 – K

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A61K 38/27 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2185999

A mammal with congestive heart failure is treated by administering to the mammal an effective amount of growth hormone. Treatment results in increased left ventricular cystolic pressure, increased left ventricular maximum, increased cardiac output, and increased stroke volume index. Treatment also results in reduced left ventricular end-diastolic pressure and reduced systemic vascular resistance. These measurements indicate improvement in cardiac function by increased ventricular contractility and decreased peripheral vascular resistance.

On traite un mammifère souffrant d'insuffisance cardiaque congestive en lui administrant une quantité efficace d'hormone de croissance. Le traitement entraîne une augmentation de la pression systolique ventriculaire gauche, une augmentation du débit maximal ventriculaire gauche, une augmentation du débit cardiaque et une augmentation de l'index de volume systolique. Ledit traitement entraîne, en outre, une baisse de la pression télédiastolique ventriculaire gauche et une baisse de la résistance vasculaire systémique. Ces mesures indiquent une amélioration de la fonction cardiaque grâce à un accroîssement de la contractilité ventriculaire et à une réduction de la résistance vasculaire périphérique.

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