Treatment of diabetes using phosphorylated insulin

Details Treatment of diabetes using phosphorylated insulin Treatment of diabetes using phosphorylated insulin

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) A61K 38/28 (2006.01) C07K 1/113 (2006.01)

Patent

CA 2165951

Phosphorylated insulins, which can be prepared from chemically extracted pharmacological insulins by gentle treatment with phosphorous oxychloride, have been shown to have reduced bioactiviy by mouse convulsion assay, but such phosphorylated insulins reduce hyperglycemia when administered to diabetic subjects without inducing hypoglycemia.

On a démontré que des insulines phosphorylatées, pouvant être préparées à partir d'insulines pharmacologiques extraites par la voie chimique par un traitement doux à l'oxychlorure de phosphore, présentent une bioactivité réduite lors du dosage par convulsion de la souris, alors qu'ells réduisent l'hyperglycémie lorsqu'elles sont administrées à des sujets diabétiques, sans induire d'hypoglycémie.

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