Treatment of diabetes with thiazolidinedione and metformin

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4427 (2006.01) A61K 31/155 (2006.01) A61P 5/50 (2006.01)

Patent

CA 2294582

A method for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof, in a mammal which method comprises administering an effective non-toxic and pharmaceutically acceptable amount of an insulin sensitiser and a biguanide antihyperglycaemic agent, to a mammal in need thereof and a pharmaceutical composition comprising an insulin sensitiser and a biguanide antihyperglycaemic agent.

L'invention concerne une méthode de traitement et/ou de prophylaxie, chez un mammifère, du diabète sucré, des états associés à ce diabète ainsi que de certaines complications de celui-ci. Cette méthode consiste à administrer à un mammifère nécessitant un tel traitement, une dose efficace, non toxique et acceptable sur le plan pharmacologique, d'un agent de sensibilisation à l'insuline et d'un agent anti-hyperglycémiant du type biguanide. L'invention concerne également une composition pharmaceutique comprenant un agent de sensibilisation à l'insuline ainsi qu'un agent anti-hyperglycémiant du type biguanide.

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