Treatment of diet-related conditions using phospholipase-a2...

A - Human Necessities – 61 – K

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Details

A61K 31/425 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01)

Patent

CA 2565416

The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a phospholipase A2 inhibitor having comprising a substituted organic compound having a fused five-member ring and six-member ring, such as indole-containing compounds.

La présente invention fournit des procédés et des compositions pour le traitement de conditions relatives au phospholipase. En particulier, l'invention prévoit un procédé de traitement relatif à l'insuline, des conditions relatives au poids et des conditions relatives au cholestérol chez un sujet animal. Le procédé implique généralement l'administration d'un inhibiteur phospholipase A2 comprenant un composé organique substitué ayant une bague fondue à cinq organes et une bague à six organes, telles que des composés contenant des indoles.

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