Treatment of disorders of nervous systemsystem with fty720

A - Human Necessities – 61 – K

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A61K 31/137 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/26 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2539033

Methods for modulating neurogenesis in vitro and in vivo have been disclosed. The methods comprise contacting neural stem cells with an effective amount of a FTY720 compound. The neurogenesis may involve the modulation of proliferation, differentiation, migration or survival of a non-embryonic neural stem cells or progenitor cells. Also disclosed are methods for the prevention or treatment of neurological disorders including Parkinson~s desease, Parkinsonian disorders, Hutington~s disease, Alzheimer~s disease, amyotrophic lateral sclerosis, spinal ischemia, ischemic stroke, spinal cord injury, cancer-related brain injury, and cancer-related spinal cord injury, Shy-Drager syndrome, progressive supranuclear palsy, Lewy body disease, stroke, cerebral infarction, multi-infarct dementia, and geriatric dementia, comprising administering to a subject a therapeutically effective amount of a FTY720 compound.

Procédés de modulation in vitro et in vivo de la neurogenèse. Ces procédés consistent à mettre en contact des cellules souches neuronales avec une quantité efficace du composé FTY720. La neurogenèse peut impliquer la modulation de la prolifération, de la différenciation, de la migration ou de la survie de cellules progénitrices ou de cellules souches neuronales non embryonnaires. L'invention concerne également des procédés de prévention ou de traitement de troubles neurologiques consistant à administrer à un sujet une quantité thérapeutiquement efficace du composé FTY720. Les troubles pouvant être ainsi traités comprennent diverses affections du système nerveux.

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