A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/661 (2006.01) A61K 31/66 (2006.01) A61K 31/662 (2006.01) A61K 31/7072 (2006.01) A61K 45/06 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2395430
The invention provides methods for treating HIV infection in a subject in need thereof comprising lipid analogs of phosphonoformate-containing pharmaceutically active compounds. Lipid analogs contemplated for use in the practice of the present invention comprise phosphonoformates covalently linked (directly or indirectly through a linker molecule) to a substituted or unsubstituted alkylglycerol, alkylpropanediol, alkylethanediol, or related moiety. In particular, the invention provides methods for treating viral infections caused by viruses which have developed resistance to currently available antiviral agents, as well as methods comprising the use of invention compounds in combination with azidodeoxythymidine to minimize the selection of drug-resistant HIV variants during therapy.
L'invention porte sur des procédés de traitement d'infections dues au VIH chez un patient le nécessitant au moyen d'analogues lipidiques de composés à activité pharmaceutique contenant du phosphonoformate. Les analogues lipidiques utilisés dans la mise en pratique de l'invention sont des phosphonoformates liés par covalence (directement ou indirectement via une molécule de liaison) à un alkylglycérol, un, à alkylpropanediol un alkylétanediol ou à un fragment associé. L'invention porte en particulier sur des procédés de traitement d'infections virales causées par des virus ayant développé une résistance aux antiviraux actuellement disponibles, et sur des procédés utilisant lesdits composés en association avec de l'azidodésoxythymidine, pour réduire la sélection de variantes du VIH résistant aux médicaments pendant une thérapie.
Hostetler Karl Y.
Mellors John W.
Mbm & Co.
The Regents Of The University Of California
University Of Pittsburgh Of The Commonwealth System Of Higher Ed
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