Treatment of drug-resistant proliferative disorders

Details Treatment of drug-resistant proliferative disorders Treatment of drug-resistant proliferative disorders

A - Human Necessities

61

K

A61K 31/197 (2006.01) A61K 31/10 (2006.01) A61K 31/18 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2593523

.alpha.,.beta.-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competitive kinase inhibitors.

L'invention concerne des sulfones .alpha.,.beta.-insaturées, des sulfoxydes et des sulfamides représentés par la formule générale (I). Dans cette formule, Ar1, Ar2, X, n * et R désignent des éléments décrits dans la description de la présente demande. Ces composés sont destinés au traitement de maladies proliférantes résistantes aux inhibiteurs de kinases compétitifs de l'ATP.

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