Treatment of duchenne muscular dystrophy

Details Treatment of duchenne muscular dystrophy Treatment of duchenne muscular dystrophy

A - Human Necessities

61

K

A61K 31/416 (2006.01) A61K 31/4192 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2641884

There are disclosed compound of Formula (I) or (II) wherein A1, A2, A3, A4and A5, which may be the same or different, represent N or CR1, R9 represents - L - R3, in which L is a single bond or a linker group and R3 represents hydrogen or a substituent and in addition, when an adjacent pair of A1 - A4 each represent CR1, then the adjacent carbon atoms, together with their substituents may form a ring B, when A5 represents CR1, then A5 and N - R9, together with their substituents may form a ring C, or a harmaceutically acceptable salt thereof, in the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia.

La présente invention porte sur le composé représenté par la formule (I) ou (II) dans laquelle: A1, A2, A3, A4 et A5, qui peuvent être identiques ou différents, désignent N ou CR1; R9 désigne - L -R3, L désignant une liaison simple ou un groupe de liaison et R3 désignant hydrogène ou un substituant; lorsqu'une paire adjacente de A1 - A4 désigne chacune CR1, les atomes de carbone adjacents, de même que leurs substituants, peuvent former un cycle B; lorsque A5désigne CR1, A5 et N - R9, de même que leurs substituants, peuvent former un cycle C; ou un sel pharmaceutiquement acceptable de ce composé, utilisé dans la fabrication d'un médicament servant au traitement thérapeutique et/ou prophylactique de la dystrophie musculaire de Duchenne, de la dystrophie musculaire de Becker, ou de la cachexie.

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