Treatment of dystrophin family related diseases by...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2761248

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Dystrophin family, in particular, by targeting natural antisense polynucleotides of Dystrophin family. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of DMD family.

La présente invention concerne des antinucléotides antisens qui modulent l'expression et/ou la fonction de la famille de la dystrophine, en particulier, par ciblage de polynucléotides antisens naturels de la famille de la dystrophine. L'invention concerne également l'identification desdits oligonucléotides antisens ainsi que leur utilisation dans le traitement de maladies et troubles associés à l'expression de la famille de la DMD.

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