Treatment of excessive osteolyisis with indolinone compounds

Details Treatment of excessive osteolyisis with indolinone compounds Treatment of excessive osteolyisis with indolinone compounds

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/40 (2006.01) A61K 31/403 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2516786

Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.

Tels qu'ils sont décrits ici, les composés représentés par les formules I et II sont utiles pour le traitement de l'ostéolyse excessive par inhibition du développement des ostéoclastes induits par M-CSF. Ces composés conviennent également pour inhiber la phosphorylation de CSF1R, et pour le traitement de cancers exprimant CSF1R.

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