Treatment of female sexual dysfunction

Details Treatment of female sexual dysfunction Treatment of female sexual dysfunction

A - Human Necessities

61

K

A61K 31/557 (2006.01) A61K 9/00 (2006.01) A61K 31/00 (2006.01) A61K 31/15 (2006.01) A61K 31/21 (2006.01) A61K 31/295 (2006.01) A61K 31/48 (2006.01) A61K 31/5377 (2006.01) A61K 31/5575 (2006.01) A61K 31/5585 (2006.01) A61K 31/56 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2306837

Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.

L'invention concerne des procédés et formulations de traitement du dysfonctionnement sexuel chez la femme. On administre dans le vagin, la zone vulvaire ou l'urètre d'une personne subissant ce traitement, une composition pharmaceutique formulée de manière à contenir un agent vaso-actif choisi. Des agents vaso-actifs appropriés sont représentés par des vasodilatateurs, notamment des prostaglandines naturelles, des dérivés de synthèse de prostaglandines, des facteurs endothéliaux de relaxation amenant une dilatation vasculaire, des agonistes du polypeptide intestinal vaso-actif, des relaxants de la fibre musculaire lisse, des inhibiteurs de leucotriènes, et autres. Ces formulations sont également utiles pour prévenir l'apparition d'infections aux levures, pour améliorer le tonus musculaire vaginal et la santé des tissus, accroître la lubrification vaginale et minimiser l'excès de dépôt de collagène. L'invention concerne également un dispositif clitoridien d'apport de médicament.

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