A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/407 (2006.01) A61K 33/06 (2006.01) A61K 33/40 (2006.01)
Patent
CA 2306748
A method of treating fibromyalgia-like complaints (i.e., fibromyalgia, chronic fatigue syndrome and irritable bowel syndrome) in a patient, the method comprising: administering to the patient an 1H-indole- 3-methanol compound (e.g., 1H-indole-3-methanol, ascorbigen, bis(3-indolyl) methane, indolo[3,2-b(carbozole)], 2-(indol-3- ylmethyl)-3,3'-diindolylmethane, 5,6,11,12,17,18-hexahydro- cyclonona[1,2-b; 4,5-b'; 7,8-b"]triindole, 1H-indol-3-yl methoxy methane, ethoxy 1H-indol-3-yl ethoxy methane, other ethers of 1H-indole-3-methanol) in a medically acceptable manner in a pharmaceutically effective amount on a regular basis. It has been found that the administration of such indoles, particularly 1H-indole-3-methanol, greatly mitigates the most severe symptoms of fibromyalgia. Patients with fibromyalgia have reported a decrease in pain, less fatigue, improved sleep patterns, and an improved sense of well being resulting from the oral administration of pharamceutically effective amounts of an 1H-indole-3-methanol compound each day.
L'invention concerne le traitement, chez un patient, de symptômes en rapport avec la fibromyalgie tels que la fibromyalgie, le syndrome de fatigue chronique et le syndrome du côlon irritable. Le procédé consiste en ce qui suit: prendre un composé de 1H-indole-3-méthanol (p.ex., 1H-indole-3-méthanol, ascorbigène, bis(3-indolyl)méthane, indolo[3,2-b(carbazole)], 2-(indol-3-ylméthyl)-3,3'-diindolylmétane, 5,6,11,12,17,18-hexahydrocyclonona[1,2-b;4,5-b';7,8-b"]triindole, 1H-indol-3-yl méthoxy méthane, éthoxy 1H-indol-3-yl éthoxy méthane, d'autres éthers de 1H-indole-3-méthanol) et l'administrer régulièrement au patient de façon médicalement acceptable et dans des quantités pharmaceutiquement efficaces. On a découvert que l'administration de ces composés indoliques, en particulier du 1H-indole-3-méthanol, permet d'alléger fortement les symptômes les plus graves de fibromyalgie. On a constaté que les patients souffrant de fibromyalgie éprouvent moins de douleurs et de fatigue, dorment mieux et retrouvent une sensation de bien-être, et ce au terme d'une administration quotidienne par voie orale de quantités pharmaceutiquement efficaces d'un composé de 1H-indole-3-méthanol.
Andrus G. Merrill
Arffmann Kathleen
Designed Nutritional Products Inc.
Oyen Wiggs Green & Mutala Llp
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