Treatment of glial cell derived neurotrophic factor (gdnf)...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/113 (2010.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2752239

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Glial cell derived neurotrophic factor (GDNF), in particular, by targeting natural antisense polynucleotides of Glial cell derived neurotrophic factor (GDNF). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of GDNF.

La présente invention concerne les oligonucléotides antisens qui modulent l'expression et/ou la fonction du facteur neurotrophique dérivé des cellules gliales (GDNF), en particulier en ciblant les polynucléotides antisens naturels dudit facteur neurotrophique dérivé des cellules gliales (GDNF). L'invention porte également sur l'identification desdits oligonucléotides antisens et sur leur utilisation dans le cadre du traitement des maladies et troubles associés à l'expression du GDNF.

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