Treatment of graft-versus-host disease

Details Treatment of graft-versus-host disease Treatment of graft-versus-host disease

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/16 (2006.01) A61K 38/20 (2006.01) A61K 47/48 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2661924

Methods for treating graft-versus-host disease, methods for reducing symptoms of graft-versus-host disease, and methods of reducing the severity of graft-versus-host disease in a patient are disclosed. The methods comprise administering to the patient a therapeutically effective amount of an IL-27 antagonist in combination with a pharmaceutically acceptable vehicle. IL-27 antagonists include soluble IL-27RA proteins and antagonists that comprise an antigen-binding site of an antibody.

L'invention a pour objet des procédés de traitement de la réaction de greffe contre hôte, des procédés de réduction des symptômes de la réaction de greffe contre hôte et des procédés de diminution de la sévérité de la réaction de greffe contre hôte. Les procédés comprennent l'administration au patient d'une quantité thérapeutiquement efficace d'un antagoniste de l'IL-27 associé à un véhicule pharmaceutiquement acceptable. Les antagonistes de l'IL-27 comprennent des protéines solubles IL-27RA et des antagonistes qui comprennent eux-mêmes un site de liaison d'antigène d'un anticorps.

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