Treatment of haemorrhagic shock using complement 5a receptor...

Details Treatment of haemorrhagic shock using complement 5a receptor... Treatment of haemorrhagic shock using complement 5a receptor...

A - Human Necessities

61

K

A61K 38/12 (2006.01) A61P 7/08 (2006.01)

Patent

CA 2557615

This invention relates to methods of treatment of haemorrhagic shock, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to act as antagonists of the C5a receptor. In one embodiment the compounds are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the invention are disclosed.

La présente invention concerne des méthodes de traitement du choc hémorragique et notamment le traitement de cette condition avec des composés peptidiques et peptidomimétiques cycliques qui ont la capacité d'agir en tant qu'antagonistes du récepteur C5a. Dans une forme de réalisation, les composés sont actifs contre les récepteurs C5a sur les macrophages et les leucocytes polymorphonucléaires. Cette invention se rapporte également aux composés particulièrement préférés destinés à être utilisés dans l'invention.

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