C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/02 (2006.01) A61K 31/435 (2006.01) C07D 471/08 (2006.01) C07D 471/10 (2006.01)
Patent
CA 2141366
The use of 3,7,9,9-tetrasubstituted 3-phenylsulfonyl- 3,7-diazabicyclo[3.3.1]nonane compounds for treating cardiac arrhythmias in larger mammals including humans; novel antiarrhythmically active 3,7,9,9-tetrasubstituted compounds corresponding to the general formula Ia Image Ia in which R1 is an alkyl group having 1-6 carbon atoms or a cycloalkylalkyl group having 4-7 carbon atoms, R2 is lower alkyl, and R3 is lower alkyl, or R2 and R3 together form an alkylene chain having 3-6 carbon atoms, R4' is cyano, an R6-O-CO- group in which R6 is lower alkyl, an R7-SO2-NH- group in which R7 is lower alkyl, or an R8-CO-NH- group in which R8 is lower alkyl or a phenyl group which is optionally substituted by halogen, cyano, nitro or an R9-SO2- radical in which R9 is lower alkyl, or an imidazolyl radical located in position 4 of the phenyl ring, and R5 is hydrogen or halogen, and physiologically acceptable acid addition salts thereof, and processes and intermediates for preparing them.
Brueckner Reinhard
Farjam Arman
Schoen Uwe
Ziegler Dieter
Kali-Chemie Pharma Gmbh
Swabey Ogilvy Renault
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