A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7076 (2006.01) A61P 9/00 (2006.01) A61P 9/06 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01)
Patent
CA 2392369
The present invention discloses a method for treating heart rhythm disturbances in a mammal in need thereof by the administration of N6- substituted-5'-(N-substituted)carboxamidoadenosines. More particularly, the invention is directed to a method for treatment of heart rhythm disturbances in a mammal that would benefit from the induction of negative dromotropic and/or negative chronotropic actions, comprising the administration to said mammal of an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt or ester thereof; wherein R1 is C3-7 secondary alkyl, or C3-8 cycloalkyl; and R2 is C1-4 alkyl or C3-5 cycloalkyl. The invention is also directed to novel dosage forms comprising said compounds.
L'invention concerne une méthode permettant de traiter les troubles du rythme cardiaque chez un mammifère qui en a besoin en lui administrant des carboxamidoadénosines N?6¿-substitutées-5'-(N-substitutées). D'une manière plus spécifique, l'invention concerne une méthode permettant de traiter les troubles du rythme cardiaque chez un mammifère qui tirerait avantage de l'induction d'actions dromotropes négatives et/ou chronotropes négatives consistant à administrer à ce mammifère un quantité efficace d'un composé représenté par la formule (I) ou un sel ou ester pharmaceutiquement acceptable de ce composé. Dans cette formule R¿1? représente un alkyle secondaire C¿3-7? ou un cycloalkyle C¿3-8?; et R¿2? représente un alkyle C¿1-4? ou un cycloalkyle C¿3-5?. L'invention concerne également de nouvelle formes posologiques contenant ces composés.
Aderis Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
LandOfFree
Treatment of heart rhythm disturbances with... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of heart rhythm disturbances with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of heart rhythm disturbances with... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1418554