Treatment of hematologic malignancies associated with...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 31/196 (2006.01) A61K 31/573 (2006.01) A61K 31/675 (2006.01) A61K 31/7076 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2350058

A method of treating hematologic malignancies associated with a high number of circulating tumor cells by the administration of a therapeutic chimeric anti- CD20 antibody. These malignancies include in particular B-prolymphocytic leukemia (B-PLL), chronic lymphocytic leukemia (CLL), and transformed non- Hodgkin's lymphoma.

L'invention concerne une méthode de traitement d'affections malignes hématologiques associées à un nombre élevé de cellules tumorales en circulation. Cette méthode consiste à administrer un anticorps chimère anti-CD 20 thérapeutique. Lesdites affections malignes comprennent notamment la leucémie prolymphocytaire B (B-PLL), leucémie prolymphocytaire chronique (CLL) ainsi que le lymphome non hodgkinien transformé.

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