A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/229, 167/233
A61K 31/455 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 498/18 (2006.01)
Patent
CA 2012978
The disclosure describes the administration of macrolide compounds having the structure: (see formula I) wherein R1 is hydroxy or protected hydroxy, R2 is hydrogen, hydroxy or protected hydroxy, R3 is methyl, ethyl, propyl or a11y1, R4 is hydroxy, methoxy or oxo (=O), n is an integer of 1 or 2 and the symbol of a line and a dotted line is a single bond or a double bond, provided that R2 is not protected hydroxy when R4 is hydroxy or oxo, and salts thereof, for regener- ating mammal liver tissue, stimulating hypertrophy and hyperplasia of hepatocytes and treating hepatic disease.
Francavilla Antonio
Starzl Thomas E.
Todo Satoru
Francavilla Antonio
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Starzl Thomas E.
Todo Satoru
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