Treatment of hibernating myocardium and diabetic...

Details Treatment of hibernating myocardium and diabetic... Treatment of hibernating myocardium and diabetic...

A - Human Necessities

61

K

A61K 38/26 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2395165

Hibernating myocardium is characterized by viable myocardium with impaired function due to localized reduced perfusion. Hibernating myocytes retain cellular integrity, but cannot sustain high-energy requirements of contraction. High plasma levels of catecholamines, such as norepinepherine, are believed to be predictive of mortality from hibernating myocardium. Likewise, high levels of catecholamines lead to cardiomyopathy in patients with diabetes. GLP-1 reduces plasma norepinepherine levels, and it thus is useful in a method of treating hibernating myocardium or diabetic cardiomyopathy.

Le myocarde hibernant se caractérise par une atteinte des fonctions du myocarde viable imputable à une réduction localisée de l'irrigation sanguine. Les myocytes hibernants conservent leur intégrité cellulaire, mais ils sont incapables de faire face aux exigences de puissance de la contraction. Il est admis de penser que les niveaux élevés du plasma en catécholamines, et notamment la norépinéphérine, permettent de prévoir la mortalité à partir du myocarde hibernant. De la même façon, les niveaux élevés en catécholamines aboutiraient à une cardiomyopathie chez les patients diabétiques. Réduisant les niveaux en norépinéphérine du plasma, le GLP-1 convient ainsi en traitement contre le myocarde hibernant ou la cardiomyopathie diabétique.

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