C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61K 31/47 (2006.01) A61K 31/70 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2256589
The present invention relates to therapeutic protocols and pharmaceutical compositions designed to target topo (I) for the treatment of HIV infection. The invention relates to therapeutic modalities and pharmaceutical compositions for the treatment of HIV-infection using human topo (I) and its interaction with HIV gag and RT as a target for intervention. The invention further relates to the use of human topo (I) to enhance the activity of RT. The present invention also relates to the expression of human topo (I) in transgenic animals, in particular mice, as a system to study the HIV life cycle and the screen agents for their ability to interfere with the HIV life cycle.
La présente invention concerne des protocoles thérapeutiques et des compositions pharmaceutiques destinés à cibler la topoisomérase I (topo I) afin de traiter l'infection par VIH. Cette invention se rapporte à des modalités thérapeutiques et des compositions pharmaceutiques permettant de traiter l'infection à VIH en utilisant comme cible de l'intervention la topo I humaine et son interaction avec la gag et la transcriptase inverse (TI) du VIH. L'invention concerne également l'utilisation de la topo I dans le but de stimuler l'activité de la TI. La présente invention concerne également l'expression de la topo I humaine chez des animaux transgéniques, en particulier des souris, comme système permettant d'étudier le cycle de vie du VIH et de cibler des agents capable d'entraver le cycle de vie du VIH.
Hall William W.
Takahashi Hidehiro
Osler Hoskin & Harcourt Llp
The Rockefeller University
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