Treatment of hiv-infection by interfering with host cell...

Details Treatment of hiv-infection by interfering with host cell... Treatment of hiv-infection by interfering with host cell...

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61K 38/52 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 31/18 (2006.01) C07K 16/40 (2006.01) C12Q 1/533 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2248192

There is disclosed pharmaceutical compositions for the treatment of HIV- infection using cyclophilin A and its corresponding human cellular binding partner as a target for intervention. There is further disclosed a method of using cyclophilins, anti-cyclophilin antibodies, and pegylated cyclosporin A as a treatment for HIV-infection. The present invention further provides screening assays for the identification of compounds which inhibit the interaction of cyclophilin and its cellular receptor.

On décrit des compositions pharmaceutiques pour traiter l'infection à VIH, ce traitement consistant à utiliser la cyclophiline A ainsi que le partenaire de liaison cellulaire, humain et correspondant de celle-ci, en tant que cible d'intervention. On décrit en outre un procédé d'utilisation de cyclophilines, d'anticorps dirigés contre les cyclophilines, et de la cyclosporine A polyéthylèneglycolée en tant que traitement de l'infection à VIH. La présente invention concerne encore des méthodes de criblage destinées à identifier des composés inhibant l'interaction entre la cyclophiline et le récepteur cellulaire de celle-ci.

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