A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/425 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01)
Patent
CA 2565448
The present invention provides methods for the treatment of conditions associated with dislipidemia, including hypercholesterolemia and hypertriglyceridemia, as well as conditions associated with cardiovascular disease, including atherosclerosis and coronary artery disease. The method generally involves identifying a subject as a member of a population at risk of one or more of obesity, insulin resistance or diabetes mellitus, and administering an effective amount of a phospholipase-A2 inhibitor (such as a phospholipase-A2 IB inhibitor) to the subject. Preferred phospholipase A2 inhibitors can comprise a substituted organic compound having a fuse five- member ring and six-member ring, such as indole compounds or indole-related compounds, or salts thereof.
La présente invention concerne une méthode de traitement d'états associés à la dislipidémie, y compris l'hypercholestérolémie et l'hypertriglycéridémie, ainsi que des états liés à des maladies cardiovasculaires, telles que l'athérosclérose et la coronaropathie. La méthode consiste généralement à: identifier un sujet membre de la population exposée à l'obésité, à la résistance à l'insuline et/ou au diabète sucré; et administrer audit sujet une quantité efficace d'un inhibiteur de la phospholipase-A2 (tel qu'un inhibiteur de la phospholipase-A2 IB). Des inhibiteurs préférés de la phospholipase-A2 peuvent comprendre un composé organique substitué présentant un noyau condensé à cinq chaînons et un noyau à six chaînons, tel que des composés d'indole ou des composés associés à l'indole, ou leurs sels.
Buysse Jerry M.
Chang Han Ting
Charmot Dominique
Cope Michael James
Hui David
Ilypsa Inc.
Ridout & Maybee Llp
LandOfFree
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