A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) C07K 14/31 (2006.01)
Patent
CA 2575406
The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor~ targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody re~sponse and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent pro~vides enhanced therapeutic effects in a treated animal.
Cette invention a pour objet des procédés de traitement des mammifères souffrant, par exemple, de maladie hyperproliférante comme le cancer, par administration d~un super-antigène ciblant la tumeur et d~un agent chimiothérapeutique, l~administration de ceux-ci permettant de réduire la réponse des anticorps et de développer la réponse du lymphocyte T. Le super-antigène, de type sauvage ou modifié, est mêlé à un groupe caractéristique de recherche de cible, tel qu~un anticorps ou un fragment actif d~anticorps. L~administration combinée d~un super-antigène et d~un agent chimiothérapeutique a, sur un animal traité, des effets thérapeutiques améliorés.
Forsberg Goran
Hedlund Gunnar
Wallen-Ohman Marie
Active Biotech Ab
Gowling Lafleur Henderson Llp
LandOfFree
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