A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) A61K 38/12 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2542510
This invention relates to methods of treatment of hypersensitivity conditions such as asthma and other allergic conditions, and especially to treatment of these conditions with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the methods of the invention are disclosed.
L'invention concerne des procédés de traitement d'états d'hypersensibilité tels que l'asthme et autres états allergiques, et notamment des procédés de traitement de ces états à l'aide de composés peptidiques et peptidomimétiques cycliques aptes à moduler l'activité des récepteurs couplés à une protéine G. Ces composés, de préférence, agissent comme antagonistes du récepteur C5a, et sont actifs contre les récepteurs C5a de leucocytes et macrophages polymorphonucléaires. L'invention concerne enfin les composés préférés utilisés dans ces procédés.
Shiels Ian Alexander
Taylor Stephen Maxwell
Gowling Lafleur Henderson Llp
Shiels Ian Alexander
Taylor Stephen Maxwell
The University Of Queensland
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