Treatment of immunologic and hematologic disorders with...

Details Treatment of immunologic and hematologic disorders with... Treatment of immunologic and hematologic disorders with...

A - Human Necessities

61

K

A61K 38/30 (2006.01) A61K 38/17 (2006.01) A61P 7/06 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2172158

This invention includes a method of treating subjects with immunologic and hematologic disorders, such as immune deficiencies and anemias characterized by deficient total hemoglobin. The treatment includes administering to the subject insulin-like growth factor binding protein-3 (IGFBP-3), alone or in a complex including an insulin-like growth factor (IGF), in an amount sufficient to improve the immunologic and/or hematologic disorder, for example, increasing the level of total hemoglobin or improving immune deficiencies, such as occur post-chemotherapy. Another aspect of the invention includes administering IGFBP-3 alone to treat IGF-driven lymphoproliferative conditions, such as leukemias, inflammatory skin diseases, and nasal polyps.

Méthode de traitement de sujets souffrant de troubles immunologiques et hématologiques, tel que des déficiences immunitaires et des anémies caractérisées par une déficience de l'hémoglobine totale. Ledit traitement consiste à administrer au sujet une protéine 3 se liant au facteur de croissance proche de l'insuline (IGFBP-3) seule ou dans un complexe comportant un facteur de croissance proche de l'insuline (IGF), en quantité suffisante pour remédier au trouble immunologique et/ou hématologique, par exemple en augmentant le taux d'hémoglobine totale ou en remédiant aux déficiences immunitaires, telles que celles qui apparaissent après une chimiothérapie. Dans un autre aspect de la présente invention, on administre IGFBP-3 seule pour traiter des états pathologiques lymphoprolifératifs induits par IGF, tels que des leucémies, des maladies inflammatoires de la peau et des polypes nasaux.

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