A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/34 (2006.01) A61K 31/365 (2006.01) A61K 31/415 (2006.01) A61K 31/4375 (2006.01) A61K 31/616 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2422064
The present invention provides for methods for treating or preventing an inflammatory disease or condition in a mammalian patient in need of such treatment comprising administering to said patient a cyclooxygenase-2 specific inhibitor in combination with an .alpha.V.beta.3, .alpha.V.beta.5 and/or .alpha.V.beta.6 integrin receptor antagonist in an amount effective to treat or prevent the inflammatory disease or condition. The present invention also provides for pharmaceutical compositions for the treatment or prevention of an inflammatory disease or condition. Further, the invention provides for the manufacture of a medicament useful in the treatment or prevention of an inflammatory disease or condition.
L'invention concerne des procédés servant à traiter ou à prévenir une maladie ou un état inflammatoires chez un mammifère, ce qui consiste à administrer audit mammifère un inhibiteur spécifique de cyclooxygénase-2 combiné à un antagoniste du récepteur d'intégrine .alpha.¿V?.beta.3, .alpha.¿V?.beta.5 et/ou .alpha.¿V?.alpha.6 en quantité efficace pour traiter ou prévenir cet état ou cette maladie inflammatoires. Elle concerne également des compositions pharmaceutiques servant à traiter ou à prévenir un état ou une maladie inflammatoires. Elle concerne, de plus, la préparation d'un médicament utile pour traiter ou prévenir un état ou une maladie inflammatoires.
Duggan Mark
Duong Le T.
Hartman George
Kimmel Donald B.
Rodan Gideon A.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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