Treatment of inflammatory airway disease

Details Treatment of inflammatory airway disease Treatment of inflammatory airway disease

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 38/04 (2006.01) A61K 38/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2565886

This invention relates to methods of treatment of inflammatory airway disease, and in particular to methods of treatment of asthma and chronic obstructive pulmonary disease. The invention is applicable to both allergic (atopic) and non-allergic (intrinsic) asthma. In one form the method comprises the step of administering an effective amount of a compound which has the ability to inhibit one or more functions of the T cell receptor (TCR) to a subject in need of such treatment, which is preferably a peptide whose sequence is derived from an invariant region of (a) the TCR.alpha.transmembrane domain; (b) the TCR.beta. transmembrane domain; (c) the TCR.alpha.intracellular domain; or (d) the CD3-.gamma., -.delta., -.epsilon., .eta. or .xi. chain.

La présente invention concerne le traitement d'affection inflammatoire des voies respiratoires, et plus particulièrement de l'asthme et de l'obstruction pulmonaire chronique, l'asthme pouvant être aussi bien allergique (atopique) que non allergique (intrinsèque). Une forme du traitement consiste en l'administration d'une quantité suffisante d'un composé capable de bloquer l'une au moins des fonctions du récepteur TCR des lymphocytes T dans le cas d'un sujet justifiant d'un tel traitement. Il s'agit de préférence d'un peptide dont la séquence est dérivée d'une région invariante (a) du domaine transmembranaire TCR¿.alpha.?, (b) du domaine transmembranaire TCR¿.beta.?, (c) du domaine intracellulaire TCR¿.alpha.? ou (d) de la chaîne CD3-.gamma., -.delta., -e, .eta. ou .xi..

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