Treatment of inflammatory bowel disease with 6-mercaptopurine

Details Treatment of inflammatory bowel disease with 6-mercaptopurine Treatment of inflammatory bowel disease with 6-mercaptopurine

A - Human Necessities

61

K

A61K 31/52 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2721728

Methods of administering a delayed release 6-mercaptopurine pharmaceutical composition to patients suffering from inflammatory bowel disease which provide for release of the 6- mercaptopurine after passage of the pharmaceutical composition through the stomach are disclosed. The methods result in significant clinical improvement despite leading to very little systemic absorption of 6-mercaptopurine and also result in very few undesirable side effects.

La présente invention a pour objet des procédés dadministration dune composition pharmaceutique de 6-mercaptopurine à libération retardée à des patients souffrant dune maladie intestinale inflammatoire qui procurent la libération de la 6-mercaptopurine après le passage de la composition pharmaceutique à travers lestomac. Les procédés entraînent une amélioration clinique significative bien quils ne mènent quà une très petite absorption systémique de la 6-mercaptopurine et ils nentraînent également que très peu deffets secondaires indésirables.

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