C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 31/336 (2006.01) C07K 14/11 (2006.01) C12N 7/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/569 (2006.01) G01N 33/92 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2190581
The present invention relates to assays for the identification of compounds that block palmitylation of influenza virus HA and inhibit virus assembly. In another aspect of the invention, the compounds which inhibit virus assembly, infection and/or replication and which demonstrate a good therapeutic index may be used to treat influenza infection. The invention is based, in part, on the Applicant's discovery that mutations of palmitylation sites of influenza virus HA affect virus formation, and that inhibition of palmitylation of HA inhibits the formation of infectious influenza virus.
L'invention concerne des analyses pour l'identification de composés bloquant la palmitylation du virus de la grippe HA et inhibant l'assemblage des virus. Dans un autre aspect de l'invention, les composés inhibant l'assemblage, l'infection et/ou la réplication virales, et présentant un bon index thérapeutique peuvent être utilisés pour traiter l'infection grippale. L'invention se base, en partie, sur la découverte par le déposant du fait que les mutations des sites de palmitylation du virus de la grippe HA altèrent la formation du virus, et que l'inhibition de la palmitylation de HA inhibe la formation du virus de la grippe infectieuse.
Mount Sinai School Of Medicine Of The City University Of New Yor
Osler Hoskin & Harcourt Llp
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