C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/265.9
C07D 241/44 (2006.01) C07C 205/12 (2006.01)
Patent
CA 1145337
X-4398A Abstract 3,4-Dihydro-3-oxoquinoxalines of the formula: Image I wherein R and R4 are individually H, NO2 or CH3O; R1 and R2 are individually H, NO2, CH3O or halo such that at least one of R, R1, R2 and R4 is other than H, such that if neither R1 and R2 is NO2 or CH3O, both R1 and R2 are individually halo, and such that one of R1 and R2 is CH3O only if one of R, R1, R2 and R4 is NO3, providing that only one of R1 and R2 is chloro; R3 is C1-C4 alkyl, C3-C6 cycloalkyl, C3-C4 alkenyl, H or 2-chloroethyl; and n is 0 or 2. These compounds, which are useful in suppressing viral infection in mammals, are prepared by reacting an o-phenylene diamine with an .alpha.-ketodibasic acid. Certain of the compounds are prepared by reacting a 6-nitro-4,5-disubstituted aniline with an alkyl malonyl chloride followed by annelation in the presence of sodium ethoxide and then treatment with phosphorus trichloride.
337952
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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